The two Premier League sides have already met this season, with City winning 1-0 at the Etihad Stadium earlier this month, and they will now meet in the last 32 of this competition at St James’ Park.
There are up to five all-top-flight clashes, with Chelsea and Brighton & Hove Albion facing off after going head-to-head in the transfer market.
Holders Manchester United face Crystal Palace, while Arsenal travel across the capital to face Brentford.
Aston Villa and Everton will meet in the West Midlands, with the Toffees coming from behind to defeat Doncaster Rovers on Wednesday night.
Liverpool has been assigned a home game against Leicester City, while Salford City’s reward for defeating Leeds United on penalties is a match against fellow North West club Burnley.
Wolverhampton Wanderers travel to Ipswich Town in the Championship, while West Ham United face EFL opposition in the form of Lincoln City.
Stoke City travel to the south coast to face Bournemouth, Luton Town travel to Exeter City, and Fulham travel to London to face Norwich City.
Draw in full
- Ipswich Town vs. Wolverhampton Wanderers
- Exeter City vs. Luton Town
- Aston Villa vs. Everton
- Manchester United vs. Crystal Palace
- Port Vale vs. Sutton United
- Bradford City vs. Middlesbrough
- Bournemouth vs. Stoke City
- Lincoln City vs. West Ham United
- Brentford vs. Arsenal
- Chelsea vs. Brighton & Hove Albion
- Salford City vs. Burnley
- Fulham vs. Norwich City
- Blackburn Rovers vs. Cardiff City
- Liverpool vs. Leicester City
- Newcastle United vs. Manchester City
- Mansfield Town vs. Peterborough United
